Sevoflurane (Sevoflurane, USP)

Product Details

The information contained in this page is intended for Indian healthcare professionals only.Indications & Usage :Sevoflurane, is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.Sevoflurane, should be administered only by persons trained in the administration of general anesthesia. Facilities for maintenance of a patent airway, artificial ventilation, oxygen enrichment, and circulatory resuscitation must be immediately available. Since level of anesthesia may be altered rapidly, only vaporizers producing predictable concentrations of sevoflurane should be used.Important Risk Information :Inhalational anesthetic agents, including sevoflurane, can cause malignant hyperthermia and should not be used in patients with known sensitivity to sevoflurane nor in patients with known or suspected susceptibility to malignant hyperthermia.Use of inhaled anesthetic agents has been associated with rare increases in serum potassium levels that have resulted in cardiac arrhythmias and death in pediatric patients during the postoperative period. Patients with latent as well as overt neuromuscular disease, particularly Duchenne muscular dystrophy, appear to be most vulnerable. Concomitant use of succinylcholine has been associated with most, but not all of these cases. Despite the similarity in presentation to malignant hyperthermia, none of these patients exhibited signs or symptoms of muscle rigidity or hypermetabolic state.Sevoflurane, exposures should not exceed 2 MAC hours at flow rates of 1 to <2 L/min. Fresh gas flow rates <1 L/min are not recommended.Because clinical experience in administering sevoflurane to patients with renal insufficiency (creatinine >1.5 mg/dL) is limited, its safety in these patients has not been established.Rare cases of seizures have been reported in association with sevoflurane use, the majority of which have occurred in children and young adults.Bronchospasm, laryngospasm and increased cough have been reported in association with sevoflurane.